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Metabolic Pathways Underlying Cow’s Milk Allergy in Children: a Metabolomics Approach

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Category
Ph D Defense
Date
2022-10-03 17:00
Venue
Universiteit Gent, Campus Merelbeke, Auditorium D - Salisburylaan 133, 9820 Merelbeke
Gent

Promovendus/a: Ellen De Paepe

Promotor(en): Prof. dr. Lynn Vanhaecke, prof. dr. Eric Cox

Over the last decades, food allergies (FAs) have become a growing epidemic, especially in industrialized countries. One of the first allergies to occur in early childhood is cow’s milk allergy (CMA), which is a first indication that the immune system is not developing properly. Indeed, the majority of children with CMA outgrow this allergy, but develop other atopic diseases later in life, including atopic dermatitis, allergic rhinitis, and asthma. This phenomenon is also described as the atopic march. Despite the increasing prevalence of FAs and more specifically CMA, current diagnostic, treatment, and prevention strategies are unfortunately insufficient, thereby negatively affecting the quality of life of the patients and their caretakers. In this regard, more research is urgently needed to unravel the pathophysiology behind this disease. Therefore, the overarching aim of this Ph.D. thesis was to contribute to elucidating the metabolic disturbances that precede or accompany CMA development. This was effectuated by using untargeted ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS)- based metabolomics and/or lipidomics in an in vivo murine model, a pediatric patient cohort (n = 81) and an in vitro gastrointestinal digestion model.

 
 

All Dates

  • 2022-10-03 17:00

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